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Dr. Nathan Oyler
Formal Education University of Washington, Seattle, WA Doctor of Philosophy, Physical Chemistry Sep. 1996 – Aug. 2000 University of Washington, Seattle, WA Master of Science, Chemistry Sep. 1994 – Aug. 1996 University of Arizona, Tucson, AZ Bachelor of Science, Chemistry Jan. 1991 – Jun. 1994 Scottsdale Community College, Scottsdale, AZ Transferred to Univ. of Arizona Sep. 1989 – Dec. 1990 Academic Experience Assistant Professor, University of Missouri-Kansas City 2005 – Present College of Arts and Sciences Department of Chemistry Research Experience University of Missouri-Kansas City Kansas City, MO Assistant Professor (Solid State Nuclear Magnetic Resonance) 2005 - Present Devised and directed an ongoing project to determine the secondary and tertiary structure of the amyloidogenic protein b₂-microglobulin that is that is found in dialysis-related amyloidosis. The project is initially focused on the structure determination of fragments suspected to be the primary amyloid forming regions of the protein. Directed the construction of a two channel (HX) 3.2mm Magic Angle Spinning probe for solid-state NMR studies. National Institutes of Health (LCP/NIDDK) Bethesda, MD Research Fellow (Solid State Nuclear Magnetic Resonance) 2004 - 2005 Postdoctoral Fellow (Solid State Nuclear Magnetic Resonance) 2001 - 2004 Supervisor: Robert Tycko, PhD. Involved in a large-scale project to determine the secondary and tertiary structure of the b- amyloid peptide important in Alzheimer’s disease. Extended previous n-spin SSNMR simulation code to include a pseudo dimension consisting of phase shifts and to allow for an arbitrary n-dimensional RF pulse sequence. Developed a method to generate high orders of multiple quantum in very fast spinning MAS experiments. Developed a method to determine orientational constraints on the internal structure of b-amyloid fibrils using solid state NMR of fibrils adsorbed to a surface. Resurrected and operated a tapping mode atomic force microscope to acquire images of fibrils adsorbed to a surface. Synthesized and purified various peptides using a commercial peptide synthesizer and HPLC. University of Washington Seattle, WA Research Assistant (Solid State Nuclear Magnetic Resonance) 1994 – 2000 Supervisor: Professor Gary Drobny Developed n-spin SSNMR density matrix simulation code written in C++. The code may be used to simulate nearly arbitrary 1-D, 2-D, and synchronous sampling experiments. Extensively involved in projects to determine the structure of small biologically relevant molecules including peptides, nucleosides and short DNA fragments. Developed the use of ¹⁵N-¹⁵N DRAWS, a homonuclear dipolar recoupling technique, as a tool to measure distances in peptides and nucleosides. Designed, maintained, and/or repaired equipment including high/low/bandpass RF filters, duplexors, MAS spinning systems, and NMR probe components. University of Arizona Tucson, AZ Research Assistant (Computational Chemistry) 1993 – 1994 Supervisor: Professor Ludwik Adamowicz Modeled the behavior of HF in the solution state by ab initio calculations. Developed software in C to perform large scale calculations of various size clusters of HF molecules (a wrapper function to run the GAUSSIAN 90 program). Extensively used the GAUSSIAN90 program to study electron attachment to nucleic acid bases in the gas phase. University of Alberta Edmonton, Alberta Research Assistant (Lipid Biochemistry) Summer 1992 Supervisor: Professor Dennis Vance Assisted in experiments performed on Schlerynchyma (skin) cells to help determine the biological pathways used in the production of phospholipids. Performed a variety of experiments including radioisotope labeling and detection in cells. Maintained the Schlerynchyma cell line. Honors and Awards Dean’s List (U. of Arizona) Outstanding Undergraduate Poster Award (U. of Arizona) Bernard Nist Fellowship (U. of Washington) Societies and Professional Activitites American Chemical Society Member Peer Reviewer for Spectrochimica Acta.

Dr. Nathan Oyler